shell386.exe is known to be a type of virus. The correct course of action is to remove this file, after backing up your computer, and scanning for more viruses.

Trojan.W32.RealSearch is a type of malware, and shell386 is linked to it. Since viruses and non-harmful files can have the same names, it is important that you backup your computer before deleting files indiscriminately.

This free scan of your computer will help you to not delete any important programs.

Since shell386.exe was found on your computer, additional viruses and adware are probably lurking, undiscovered. This free computer scan is probably the best way to make sure you don't experience future issues with spyware files.